WebSemantic Scholar extracted view of "Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells." by E. Dufour et al. WebMay 11, 2010 · The results of the present study indicate that the in vivo rat skin photoMNT can detect photoclastogenicity following treatment with the known photogenotoxin and photocarcinogen, 8-MOP. Given the association between MN induction and cancer, the assay may also provide a promising tool for the early detection of photocarcinogenesis …
Photosensitizing medications and photocarcinogenesis
WebThe oxygen radical scavengers catalase, superoxide dismutase and N, N'-dimethylurea modulated the photoclastogenicity and phototoxicity but had no influence on the effects … WebTo explore this further, four coded compounds (aminotriazole, propantheline bromide, cycloheximide and disulfoton) were evaluated for their potential response in a photoclastogenicity assay in cultured Chinese hamster ovary (CHO) cells. redondo beach tapestry collection
Note for guidance on photosafety testing - European …
WebSep 1, 1996 · The oxygen radical scavengers catalase, superoxide dismutase and N, N'-dimethylurea modulated the photoclastogenicity and phototoxicity but had no influence on the effects in the Comet and Ames tests. It thus appears that different kinds of mechanism are responsible for toxicity and clastogenicity on the one side and DNA breakage and … WebSep 5, 2006 · Zinc oxide (ZnO), a widely used ingredient in dermatological preparations and sunscreens, is clastogenic in vitro, but not in vivo. Given that ZnO has an approximately … WebJun 10, 2012 · Positioning of photogenotoxicity within a photosafety testing strategy 5TH IWGT - Basel 2009 Photogenotoxicity Group Group‘s consensus statement: • No added value of photogenotoxicity data for overall photosafety assessment • Therefore no photogenotoxicity testing recommended • Proposals for better triggers for testing still … richelieu black knobs